Oral CBD Gummies

CBD Gummies Near Me: 10 Best Products Oros CBD Gummies are the CBD backed oral gummies formulated using pure extracts of hemp plant. It is enriched with multiple health benefits and therapeutic properties to promote healthy healing. Cannabidiol: Promise and Pitfalls Over the past few years, increasing public and political pressure has supported legalization of medical marijuana. One of the main thrusts in this effort has

CBD Gummies Near Me: 10 Best Products

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Do you want to buy CBD gummies but don’t know where to start? With so many products on the market, it can be difficult to determine which one is right for you. In this article, we will recommend 10 of the best CBD gummy products available today.

We’ll also provide information on what to look for when purchasing CBD gummies and how they can benefit your health.

What is CBD?

Cannabidiol, or CBD, is a natural compound found in the cannabis plant. It has been shown to provide a variety of health benefits, including relief from anxiety, pain, and inflammation.

CBD works with the body by interacting with the endocannabinoid system. This system is responsible for maintaining balance in the body and is known to play a role in many functions, including sleep, mood, and pain response. CBD can help to support the endocannabinoid system by boosting its function.

What to Look for When Buying CBD Gummies

When purchasing CBD gummies, it is important to look for products that are made with quality ingredients and that have been tested by a third party. It is also important to check the dosage of the product and make sure that it is appropriate for your needs.

Quality

CBD gummies will typically contain CBD oil that has been extracted from the cannabis plant using a solvent-free method. The gummies will also be sweetened with organic cane sugar and will not contain any artificial flavors, colors, or preservatives.

Potency

The potency of the CBD gummy will vary depending on the brand. It is important to check the dosage before purchasing a product to make sure that it is appropriate for your needs.

Ingredients

When looking for CBD gummies, it is important to check the ingredients list to make sure that all of the ingredients are natural and organic. Gummies that contain artificial flavors, colors, and preservatives should be avoided.

Third-Party Testing

It is important to purchase CBD gummies that have been tested by a third party to ensure quality and safety. Look for products that have a certificate of analysis (COA) available on their website.

Flavor

CBD gummies come in a variety of flavors, including grape, orange, and strawberry. Some brands also offer sour gummies.

Packaging

CBD gummies are typically packaged in a resealable bag or container. This allows you to store the gummies for later use.

CBD Source

When looking to buy CBD gummies, it is important to know the source of the CBD. Some CBD gummies may not be pure and may contain other chemicals or ingredients. It is important to find a reputable source for CBD gummies to ensure you are getting the best possible product.

Extraction Method

When looking for CBD gummies, it is important to consider the extraction method. Some CBD gummies may not be pure and may contain other chemicals or ingredients. It is important to find a reputable source for CBD gummies to ensure you are getting the best possible product.

How CBD Gummies Can Benefit Your Health

There are many ways that CBD gummies can benefit your health. We’ve noticed people have started sleeping better, feel more relaxed, and can live a happier life after taking CBD gummies.

While we’re not health professionals and cannot guarantee any results, we can share what CBD gummies do for others to improve their life. It’s always best to discuss CBD gummies with a doctor before attempting to buy any of the 10 best products we have featured here today.

CBD gummies have been shown to help people with:

Inflammation

CBD helps with inflammation by reducing the number of inflammatory cells in the body.

Joint Health

There are many ways that CBD helps with joint health. CBD can help by reducing inflammation, repairing damaged cells, and blocking pain signals.

Anxiety and Depression

CBD interacts with the brain in a way that reduces anxiety and depression. It helps to increase serotonin levels, which can improve mood. CBD can also help to reduce stress and promote relaxation.

When should I take CBD gummies?

You can take CBD gummies at any time of the day. However, it is always best to speak with a doctor before taking any kind of supplement, including CBD gummies.

Some people find that they work best when taken in the morning, while others find that they work better when taken at night. It all depends on what works best for you.

We recommend starting with a lower dosage and working your way up until you find the dosage that works best for you.

What are the side effects of CBD gummies?

The side effects of CBD gummies can vary from person to person. Some people may experience dry mouth, while others may experience drowsiness.

It is always best to speak with a doctor before taking CBD gummies, as they may be able to help you find the dosage and type of CBD gummy that is best for you.

CBD Gummies Near Me: The Top Ten Best Products

We’ve searched high and low for the best CBD gummies and have come up with the top 10 products. These products are all high-quality and can help you improve your health in a variety of ways.

As always we recommend speaking with a doctor before taking any kind of supplement, including CBD gummies. However, if you’re looking for a way to improve your health, these ten CBD gummies may be just what you need.

1. Penguin CBD Gummies

Image courtesy Penguin CBD

For anybody searching for a better-tasting CBD alternative to other products, these Penguin CBD Full Spectrum CBD gummy worms are a delicious choice. They’re covered with a sweet and sour sugar sprinkle that’ll appeal to any lovers of sour sweets.

The delicious gummies are made with a 30-count quantity of CBD, with each serving containing a 10 mg dose of pure CBD isolate.

2. Everest Full Spectrum Gummies

Image courtesy Everest

Everest’s Full Spectrum gummies are made from the finest-quality hemp cultivated in the United States and contain no artificial colors or flavors. These gummies are vegan-friendly and free of GMOs, making them appealing to a wide range of consumers.

There are 30 gummies in each package of Everest Full Spectrum Gummies, each containing 25 mg CBD and 5 mg THC. Blue Raspberry flavored gummies are also gluten-free and pesticide-free.

Consumers may purchase Everest’s Full Spectrum Gummies for a one-time fee of $75 or month for $60 per month when you get them on a subscription auto-pay service, which saves 20% on the original price.

3. CBDfx Gummies

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Mixed Berry CBD Gummies are the ideal product for you if you want to get a pure CBD experience without any other active components to muddy your cannabidiol calm.

These CBD gummies are packed with 25 mg of broad-spectrum CBD per gummy (50 mg per serving), making them a delicious way to enjoy the soothing health benefits of CBD!

4. cbdMD CBD Gummies

Image courtesy cbdMD

CBD gummies are a delicious way to get your daily CBD! CBD edibles from cbdMD, which are infused with Superior Broad Spectrum hemp extract in a precisely measured amount for each gummy, make it simple and enjoyable to consume.

Now you can mix your CBD tincture or CBD cream with a tasty dessert designed to give all-day help. CBD gummies are among the most popular and versatile CBD edibles accessible, filling a variety of niches.

5. FabCBD Chews

Image courtesy FabCBD

The 25mg Chews are ideal for whenever, anywhere. These CBD gummies are THC-FREE and a fun way to enjoy CBD no matter where you go! These FAB CBD gummies are gluten-free, non-GMO, fruit flavored, and vegetarian.

Hemp gummies are great for on the go, work, and as a post-workout recovery supplement. Each hemp gummy contains 25 milligrams of CBD isolate per piece.

6. Charlotte’s Web Daily Wellness CBD Gummies

Image courtesy Charlotte’s Web

Nature has the ability to improve our general health. It relieves anxiety, increases happiness, and helps you fall asleep soundly when the time comes. These delicious full-spectrum hemp extract gummies combine the power of nature – like a few hours spent outside – into one tasty package.

Every day, enjoy the benefits of these tasty CBD gummies when you buy these wellness CBD gummies.

7. Bluebird Botanicals CBD Gummies

Image courtesy Bluebird Botanicals

These CBD gummies, from aiding you in managing day-to-day pressures to assisting your muscles and joints, are the most delicious way to incorporate CBD into your daily wellness regimen.

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These gummies are made with all plant-based ingredients and a delicious lemon, watermelon, and strawberry combination.

At simply 2g of sugar per gummy, these gummies are also vegan, produced responsibly, and devoid of artificial additives or fillers. This CBD product, which includes 110+ cannabinoids as well as terpenes from the hemp plant, tastes just as delicious as it smells.

8. Zatural CBD Gummies

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At Zatural, they recognize the significance of incorporating CBD into your everyday routine, which is why they’ve developed some of the best CBD Gummies on the market. They place the needs of consumers first. You can purchase CBD Gummies from the Zatural online store and have them sent to your home in as little as 3-6 business days with just a click of a button.

9. Green Gorilla CBD Gummies

Image courtesy Green Gorilla

Supplement with CBD in a delicious way! A daily dose of our Organic Certified CBD Gummies will aid in the support of everyday recovery, mood, sleep, and general health.

These CBD gummies are non-THC and vegan, with 600 mg of organic CBD per gummy. Every batch is third-party verified by an ISO-certified lab. Each gummy has 10 milligrams of CBD and the highest quality natural ingredients available.

10. PlusCBD Oil Gummies

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These CBD-infused gummies are superior because their CBD oil comes from real agricultural hemp grown in only soil, water, and sunshine. True hemp, like all cannabis plants, contains numerous components including the cannabinoids (including CBD), terpenes, and fatty acids that allow it to be so beneficial for health.

These gummies, which are infused with a potent Extra Strength Formula extract, contain a lot more than just CBD. They also include a variety of minor cannabinoids, terpenes, and fatty acids.

How do I take CBD gummies?

There are a few ways that you can take CBD gummies. You can either eat them as you would any other gummy candy, or you can dissolve them in water or another beverage. Some people also like to chew on them for a while before swallowing.

It is possible to take too many CBD gummies. It’s important to start with a low dose and increase gradually as needed. Too much CBD can cause drowsiness, dizziness, and nausea.

If you feel dizzy after taking CBD gummies, you should drink plenty of fluids and lie down until the feeling passes. You may also want to talk to your doctor if the dizziness persists.

However, if these side effects continue please stop taking CBD gummies and reach out to a doctor for advice on proper CBD gummies dosage and options.

How long does it take for CBD gummies to work?

This is a question that is frequently asked by people who are new to CBD gummies. The answer to this question depends on a number of factors, including the dosage of CBD gummies, the individual’s metabolism, and how long it takes for the CBD to enter the bloodstream.

In general, it takes about two hours for CBD to take effect when it is taken orally. However, it can take longer for some people. If you are taking CBD gummies for the first time, it is a good idea to start with a low dosage and increase it gradually until you find the dose that works best for you.

Are CBD gummies good for me?

This is another question that is frequently asked by people who are new to CBD gummies. The answer to this question depends on the individual’s needs and goals.

CBD has a range of potential benefits, including reducing anxiety, relieving pain, and improving sleep quality. However, more research is needed to determine the long-term safety and efficacy of CBD.

If you are considering using CBD gummies, it is important to speak with a healthcare professional to determine if they are right for you.

Is there sugar in CBD gummies?

This is a question that is often asked by people who are looking for a healthier alternative to traditional candy.

CBD gummies do not typically contain sugar, but it is important to check the label before purchasing them. Some brands of CBD gummies may contain added sugar or artificial sweeteners.

Are CBD gummies legal?

CBD gummies are legal in the United States, but they may not be legal in other countries. It is important to check the laws of your country before purchasing CBD gummies.

Where can I buy CBD gummies near me?

There are a number of online retailers that sell CBD gummies, and some brick-and-mortar stores are beginning to carry them as well. It is important to do your research before purchasing CBD gummies to make sure you are buying from a reputable source.

How many CBD gummies can I take daily?

This depends on the CBD gummy product that you are using. Some products have a higher dosage per gummy, while others have a lower dosage. It is important to read the label of the product before taking it to ensure that you are taking the correct dosage.

Do CBD gummies contain THC?

THC is the compound in cannabis that gets users high. Some CBD gummies contain THC while others do not. It’s best to read the label on each product before buying CBD gummies.

You’ll want to make sure you’re buying a legal version of CBD gummies based on your local region’s laws.

What are the different types of CBD gummies to choose from?

There are different types of CBD gummies to choose from. Below are the few options to choose from when it comes to choosing the best CBD gummies for your needs:

Full-Spectrum

CBD gummies that are full-spectrum contain all the benefits of CBD oil. This means that they contain cannabinoids, terpenes, and other essential oils that can be extracted from the cannabis plant.

Full-spectrum CBD gummies are thought to be more effective than CBD gummies that are not full-spectrum. This is because they contain all the beneficial compounds that are found in the cannabis plant.

Broad-Spectrum

Broad-spectrum CBD gummies are made with CBD oil that has been extracted from the cannabis plant. This means that these CBD gummies contain all the beneficial compounds that are found in the cannabis plant, including cannabinoids and terpenes.

Broad-spectrum CBD gummies are thought to be more effective than CBD gummies that are not broad-spectrum. This is because they contain all the beneficial compounds that are found in the cannabis plant.

Isolate CBD gummies

CBD gummies that are made with isolate CBD are made from CBD oil that has been isolated from the cannabis plant. This means that these CBD gummies only contain CBD and no other cannabinoids or terpenes.

Isolate CBD gummies are thought to be less effective than full-spectrum CBD gummies. This is because they do not contain all the beneficial compounds that are found in the cannabis plant.

How do you use CBD gummies for pain?

CBD gummies can be used to manage pain in a few different ways. The first way is to simply eat one or two gummies as needed for pain relief. This is a great option if you’re looking for immediate relief from discomfort.

Another way to use CBD gummies for pain is to keep them on hand and eat them as needed for pain relief. This is a great option if you’re looking for long-term relief from discomfort.

Are CBD gummies safe for seniors?

There is no evidence that CBD gummies are unsafe for seniors, but it is always best to speak with a doctor before starting any new supplement. CBD gummies may interact with other medications a senior is taking.

It is also important to be aware that CBD gummies can have some side effects, such as dry mouth and drowsiness.

Can CBD gummies help with anxiety?

There is some evidence that CBD gummies may be helpful for people with anxiety. A study published in the Journal of Psychopharmacology showed that people who took CBD gummies experienced a decrease in anxiety levels.

What do CBD gummies make you feel like?

CBD, unlike many natural medicines, has a real impact on your own body. It takes around 15-45 minutes for CBD to work. Keep in mind that CBD is not like THC, where you feel “high,” but rather than feeling anxious or nervous, you will experience a subtle sense of calm and relaxation.

Final Thoughts CBD Gummies: 10 Best Products

If you are looking for CBD gummies, you can check out the 10 best products that we have featured in this post. All of these products come with high-quality ingredients and offer a variety of benefits. So, if you are looking for the best CBD gummies, then be sure to check out these products to choose which brand seems best for your current needs.

Sponsored Content

Poor mental wellbeing and extreme pressure is the common thing these days amongst people. Pressure, stress and depression negatively impact the mental wellbeing. It prevents people to perform at their peak both at personal and professional life. So, it is extremely important to take care of the overall wellbeing to lead a fuller and satisfying lifestyle. People struggling with the chronic issues often use OTC drugs without knowing the side effects associate with them. You must use natural remedy to overcome these chronic conditions. Oros CBD Gummies are the oral gummies designed for people who want natural and peak healing of the chronic conditions.

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Oros CBD Gummies are the CBD backed oral gummies formulated using pure extracts of hemp plant. It is enriched with multiple health benefits and therapeutic properties to promote healthy healing. With the regular use of the gummies, one can enjoy ultimate healing with instant relief from pain, anxiety and depression. These gummies are designed to nourish the psychological and physical wellbeing by treating root cause of the chronic disorders.

What is Oros CBD Gummies?

Oros CBD Gummies are the natural and healthy oral gummies backed by the extract of hemp plant leaves. It is enriched with broad spectrum CBD oil that is organically sourced for natural and instant healing. The gummies are chewable and easily digestible and with regular use of the gummies one can enjoy multiple health benefits. Oros CBD Gummies take the natural healing process of your body to its pinnacle. It ensures nourishing your psychological, physical and neurological wellbeing. It lowers the mental pressure, anxiety and stress leading to depression and allows you to have a healthy functioning mind and body. It relaxes and soothes the brain and keeps you rejuvenated and active with full energy.

Oros CBD Gummies ensure that users never feel high because there are no traces of THC component in the gummies. All the gummies are carefully formulated using CBD oil sourced organically. It is formulated at FDA approved facility using GMP Certified guidelines. Besides, the gummies are also powerful in healing the pain and swelling caused by arthritis and other injuries. It also promotes healthy healing from inflammation and it reduces associated pain and swelling. It also heightens the mobility and flexibility of your joints and help you enjoy a pain-free lifestyle.

How Does Oros CBD Gummies Work?

Understanding how Oros CBD Gummies work is important before using it. It is extremely important that you know how it works, but before knowing it you must learn about the ECS system. ECS System is the crucial part of your body that controls the major functions. As we grow older or laden with extreme pressure, the ECS system starts malfunctioning. As a result, out body stops performing at its peak and experiences different chronic conditions. Oros CBD Gummies work by releasing CBD oil in your system and it helps nourishing the ECS system. As the CBD oil triggers the receptors in your body to start activating the ECS system to work optimally. As a result, you start having better control over eating habits, sleeping patterns, cognitive wellbeing and pain management. Also Check Green Otter CBD Gummies Reviews

Besides, the CBD oil also comprises with other health benefits and therapeutic properties. It works by triggering the anti-inflammatory responses of your body and it helps controlling inflammation and swelling across body. It also promotes faster healing post workout and prevents muscle loss and straining. It also prevents bone loss due to aging and allows you to have a healthy stability. It reduces pain caused by arthritis and lubricates the joints for added flexibility and mobility. The CBD oil also helps lowering the stress hormone in body and releases serotonin that keeps your mood optimal. It minimizes stress and anxiety while keeping your mental state in calming state. It supports in having sound sleep cycles and wake up rejuvenated next day.

What are the Key Elements of Oros CBD Gummies?

Oros CBD Gummies are effective and powerful because of the components used in formulating them. The gummies are enriched with a unique blend of powerful substances, including proteins, vitamins and minerals. It has the unique combination of elements and it shows results when taken as prescribed. The body responds positively to these elements and helps nourish the system naturally.

Oros CBD Gummies are formulated with naturally sourced CBD oil and it is extracted from hemp plant leaves using CO2 extraction technology. It ensures to highest purity of the CBD oil without harmful chemicals. To double assure the quality, the CBD oil also undergoes a triple filtration technology where the THC components and other chemicals are removed efficiently. Some of the key elements of the gummies are:

  • Proteins, nutrients and vitamins
  • Natural oils such as lavender oil and coconut oil
  • Ginger Extracts
  • Apple Cider Vinegar
  • Green Tea Extract that work as mineral to relax your body and mind

All these elements are mixed in appropriate proportion to ensure highest efficiency of the gummies. It is free from harmful chemicals and artificial ingredients. So, it is 100% safe and won’t cause any negative effects to your wellbeing.

What are the Major Highlights of Oros CBD Gummies?

The major highlight of the gummies is that it is 100% natural and effective remedy. It helps your system to recover faster and stay in stable condition without chronic disorders. Some of the other highlights of the gummies worth mentioning are:

  • Physical Benefits – The CBD oil in the gummies are responsible for offering multiple physical benefits. It helps recovering faster after workouts and prevents workout-induced inflammation. The CBD Oil also interacts with the ECS system which is the biological network composed of cannabinoid receptors. As a result, it helps the body to maintain overall wellness and health.
  • Psychological Benefits – The gummies are also known for regulating the mood patterns positively while reducing stress and anxiety. It even promotes sound sleep cycles at night and supports you to manage the sense of focus and calm.
  • Neurological Benefits – CBD Oil is medically prescribed because it helps people to deal with different neurological disorders. It prevents mental issues and optimizes memory recall power. It also reduces anxiety and depression associated with migraine.

What are the Pros & Cons of Oros CBD Gummies?

Pros:

  • Natural and organic defense system against aches and pain
  • Promotes healthy cellular networks
  • Enriched with anti-inflammatory properties
  • Treats pain and aches across body
  • Promotes faster recovery post workout
  • Reduces workout-induced inflammation
  • Cures arthritis pain naturally
  • Promotes healthy mobility and flexibility
  • Relaxes the joints and muscles for a pain-free lifestyle
  • Reduces stress by offering calming effects
  • Provides relaxation and relieves stress for sound sleep patterns at night
  • Strengthens your immune system to combat against free radical damages
  • Improvises your sleep and relaxes your body and mind
  • Enhances your mood patterns
  • Improvises your metabolism to promote healthy weight loss
  • Controls unnecessary appetite and hunger pangs

Cons:

  • The gummies are not meant for people that are minors below the age of 18 years
  • There is an availability issue with Oros CBD Gummies because it is not available offline at local market. Interested buyers need to purchase it online only
  • People that are under severe medications and treatment must avoid using the gummies as it may interact with other drugs and won’t show any satisfying result.
  • Pregnant ladies and women that are breastfeeding their baby is also prevented from using the oral gummies as it may cause negative effects to your wellbeing.
  • Overdosing of the formula can cause negative effects to your wellbeing and hence it must be avoided.
  • Consultation with a doctor is necessary before using the gummies as they will assess and prescribe the right dosing of it as per your health and age.

What is the Daily Dose of Oros CBD Gummies?

The monthly supply bottle of Oros CBD Gummies comprises 20 oral gummies and the daily dose of the gummies is one oral gummy. The dosing instructions are mentioned on the label of the formula and users must follow the instructions carefully while using it.

It is necessary that users consume the gummies orally with water and avoid overdosing. It must be taken with water daily without skipping any doses to achieve satisfying results in 2-3 months. The results may show up lately if you are not using it as prescribed. Consultation with a doctor is necessary before using the gummies. Learn about the daily dosing as per your health and severity of the condition.

Is Oros CBD Gummies Safe to Use?

Yes, Oros CBD Gummies is 100% safe because it is formulated using CBD oil sourced organically. However, it is necessary that you take the doses as prescribed without surpassing the daily dose. Overdosing must be avoided as it causes negative effects to your wellbeing. So, you must consult your doctor before using the gummies and use it as prescribed to avoid overdosing.

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Where to Order Oros CBD Gummies?

As mentioned, Oros CBD Gummies is not available at local market and buyers have to order it online only directly from the official website. There is no other place from where it can be ordered other than its official website. So, visit its website to purchase the monthly supply.

The news and editorial staff of the Bay Area News Group had no role in this post’s preparation.

Cannabidiol: Promise and Pitfalls

Over the past few years, increasing public and political pressure has supported legalization of medical marijuana. One of the main thrusts in this effort has related to the treatment of refractory epilepsy—especially in children with Dravet syndrome—using cannabidiol (CBD). Despite initiatives in numerous states to at least legalize possession of CBD oil for treating epilepsy, little published evidence is available to prove or disprove the efficacy and safety of CBD in patients with epilepsy. This review highlights some of the basic science theory behind the use of CBD, summarizes published data on clinical use of CBD for epilepsy, and highlights issues related to the use of currently available CBD products.

Cannabidiol is the major nonpsychoactive component of Cannabis sativa. Over the centuries, a number of medicinal preparations derived from C. sativa have been employed for a variety of disorders, including gout, rheumatism, malaria, pain, and fever. These preparations were widely employed as analgesics by Western medical practitioners in the 19 th century (1). More recently, there is clinical evidence suggesting efficacy in HIV-associated neuropathic pain, as well as spasms associated with multiple sclerosis (1).

Basic Pharmacological Mechanisms

Cannabidiol pharmacological effects are mediated through G protein coupled receptors, cannabinoid type I (CB1) and cannabinoid type II (CB2), which are highly expressed in the hippocampus and other parts of the central nervous system (2). When activated, CB1 receptors inhibit synaptic transmission through action on voltage-gated calcium and potassium channels, which are known to modulate epileptiform and seizure activity (3). CB2 receptors are primarily expressed in the immune system and have limited expression in the central nervous system. The effects of CBD are CB2 receptor independent (3).

Studies have demonstrated that CBD has a low affinity for the CB1 receptors, but even at low concentrations, CBD decreases G-protein activity (3). CB1 receptors are expressed on many glutamatergic synapses that have been implicated in seizure threshold modulation. CBD may act at CB1 receptors to inhibit glutamate release (4). Studies have shown changes in the expression of CB1 receptors during epileptogenesis and after recurrent seizures (5). CB1 receptor expression is upregulated at GABAergic synapses and shown to be downregulated at glutamatergic synapses in epilepsy, contributing to lowering seizure thresholds.

Other targets for CBD include transient receptor potential (TRP) channels that are involved with the modulation of intracellular calcium (1, 6). Cannabinoids are highly lipophilic, allowing access to intracellular sites of action, resulting in increases in calcium in a variety of cell types including hippocampal neurons. CBD actions on calcium homeostasis may provide a basis for CBD neuroprotective properties.

Evidence in Animal Models

When administered alone, CBD is an effective anticonvulsant in maximal electrical shock (MES), magnesium-free, 4-aminopyridine, and audiogenic models (7, 8). Co-administration with AEDs leads to various effects; anticonvulsant effects of CBD are enhanced with phenytoin or phenobarbital but decreased with chlordiazepoxide, clonazepam, trimethadione, and ethosuximide. In a recent study using an acute pilocarpine model, although CBD administration reduced the number of animals displaying seizure activity, CBD did not appear to have any significant effect on the number of seizures per animal (7).

Clinical Evidence in Epilepsy

While animal experimental data clearly suggest a potential benefit, supportive clinical data are quite sparse. In a case-control study of 308 cases of new onset seizures, Brust and colleagues found that marijuana use was significantly less prevalent among men who had unprovoked seizures compared to case controls (9). This difference was not significant in women. The authors suggest a potential protective effect against seizures with marijuana use; however, this should be considered speculative.

A survey of patients seen in a tertiary epilepsy center found that 21% of patients admitted to using marijuana in the last year, and 24% of patients believed marijuana to be effective for their seizures (10). While interesting, this anecdotal observation does not rise to the level of evidence needed to evaluate a potential new therapeutic modality.

Gloss and Vickrey conducted a Cochrane systematic review of the use of CBD in the treatment of epilepsy (11). Their methodology included only those trials that were randomized and controlled and excluded case series, case reports, and expert opinion. They were able to identify only 4 randomized controlled studies reported in the literature, and they included a letter to the editor and an abstract. The total number of subjects enrolled in these studies was 48 (11–14). While only four studies and a letter to the editor were in the actual analysis, the authors included a complete reference listing of all articles reviewed for inclusion.

These reports suffered from a number of design flaws, including incomplete baseline quantification of baseline seizure frequency, indeterminate time periods for outcome determination and, in some cases, inadequate (or missing) statistical analysis—in general, a lack of sufficient detail to adequately evaluate and interpret the findings. Limitations aside, several studies did report that administration of adjunctive CBD did not result in meaningful changes in seizure frequency (11–13).

Cunha et al. reported a 2-phase pilot study of CBD versus placebo in normal volunteers and patients with refractory secondarily generalized epilepsy (14). In the first phase, 8 normal volunteers received CBD or placebo in a doubled-blind fashion, at a dose of 3 mg/kg for 30 days. The second phase was also double-blinded in 15 patients with epilepsy receiving 200 to 300 mg daily of CBD or placebo for 135 days. Patients continued baseline AED. All subjects tolerated CBD well, with no serious adverse events. Four of the epilepsy patients receiving CBD were “almost free of convulsive crisis” for the duration of the study. Three other patients receiving CBD had a partial reduction in seizures, and 1 subject had no response. Of the 7 patients receiving placebo, seizure frequency was unchanged in 6, and 1 had clear improvement in seizure control.

Using rigorous review methodology, Gloss and Vickery conclude that based on the low quality of the reports available, there is insufficient data available to draw any conclusions regarding the efficacy and or long-term safety of CBD in treating epilepsy (11). From the data available, it does appear that daily doses of 200 to 300 mg were safe in this small group of patients for a short period of time (14).

Tolerability and Drug Interactions

CBD is well tolerated in humans with doses up to 600 mg not resulting in psychotic symptoms (15). In the few small placebo-controlled studies performed, no significant CNS effects were noted. Oral CBD undergoes extensive first-pass metabolism via CYP3A4, with a bioavailability of 6%. Following single doses in humans, the half-life of CBD when taken orally is about 1 to 2 days.1 In vitro studies have shown that CBD is a potent inhibitor of multiple CYP isozymes, including CYP 2C and CYP3A (16, 17). Whether these in vitro observations are relevant at plasma concentrations likely to be seen in patients is unclear. In addition, given its metabolism via CYP3A4, clinical trials of CBD in patients receiving enzyme-inducing AEDs, such as carbamazepine or phenytoin, will require detailed pharmacokinetic studies.

A number of difficulties exist in evaluating published data on CBD or marijuana use for epilepsy. The extremely limited published studies were small, poorly described, and not well designed. Contributing to the difficulty of interpreting published studies, CBD products are not produced under the guidance of good manufacturing practices (GMP) and are not subject to regulations governing labeling, purity, and reliability. In other words, currently, there is no guarantee of consistency between products, or even differing lots produced by the same manufacturer. Without independent testing (e.g. USP certification) of CBD products for content and purity, as well as bioavailability testing of specific products, uncertainty surrounds the use of available CBD products in routine clinical settings.

Conclusions

At this time, there does seem to be a growing body of basic pharmacologic data suggesting there may be a role for CBD, especially in the treatment of refractory epilepsy. However, given the lack of well-controlled trials, we must also ask if we are getting ahead of ourselves. Clearly, this is an emotionally and politically charged issue. If this were any other uninvestigated pharmaceutical compound, would we feel as compelled to make the agent widely available before statistically valid class 1 evidence was available for review? Until data from well-designed clinical trials are available and reliable, and standardized CBD products that are produced using GMP are available, caution must be exercised in any consideration of using CBD for the treatment of epilepsy. In the meantime, based upon promising preliminary data, further clinical research should be wholeheartedly pursued.